Mechanism of Action

Overview

Semaglutide selectively activates the GLP-1 receptor: glucose-dependent insulin secretion, glucagon suppression, slowed gastric emptying, reduced caloric intake. Half-life ~7 days.

Related clinical pages

• STEP trial results
• SELECT trial results
• FLOW trial results
• Mechanism of action
• Dosing & pharmacology
• Contraindications
• Side effects