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Guide · Updated July 2026

Semaglutide Dosing Schedule — Standard Titration

Released: · Last reviewed:

Semaglutide is administered as a once-weekly subcutaneous injection. The standard titration schedule increases the dose every 4 weeks to minimize gastrointestinal side effects.

The full picture

Standard schedule: Week 1-4 at 0.25 mg, Week 5-8 at 0.5 mg, Week 9-12 at 1.0 mg, Week 13-16 at 1.7 mg, Week 17+ at 2.4 mg (maintenance). Each dose level is held for at least 4 weeks before considering escalation. The 0.25 mg starter dose is intended for tolerance only and is not therapeutic. Patients who tolerate well may reach maintenance at 16 weeks; patients who experience significant side effects may take longer or stay at a lower maintenance dose. Injection sites: abdomen, thigh, or upper arm — rotated weekly.

How NexLife handles this

NexLife is structured around clinical best practices for semaglutide. See full NexLife review.

Disclaimer: This guide is informational and does not constitute medical advice. Decisions about semaglutide should be made in consultation with a licensed healthcare provider who can review your full medical history.
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Sources & clinical references

Citations supporting clinical and regulatory statements on this page. External links open in a new tab.

Researched By Dr. Parmis · Medical Researcher · Western University of Health Sciences

Medically Reviewed By Dr. Jonathan Snipes, MD · Kim Callender, NP (FNP-BC)

Last medically reviewed: · This page is informational and does not constitute medical advice.